• Transplant research activity

    Research is a vital function of the UK Transplant team. Below are some of the major activities currently underway:

    Basic Science Research

    • PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and P13K/AKT/mTOR pathways (In vivo and In vitro models) 
    • PKI-587 and Sorafenib Targeting Ras/Raf/MAPK and PI3K/AKT/mTOR Pathways Synergistically Inhibit HCC Cell Proliferation an in vitro study 
    • Liver cancer Stem cell Markers as Predictors of Outcomes inpatients with HCC undergoing
      Liver Transplantation 
    • Inhibition of Beta-Catenin pathway in HCC proliferation 
    • ZHX2 expression as a predictor of outcomes in Hepatocellular Carcinoma  
    • Investigator-Initiated Clinical Trials 
    • Effects of Zortress┬« + Tacrolimus vs. Standard Immunosuppression on Progression of
      Coronary Artery Calcifications and Bone Disease in de novo renal Transplant Recipients
    • Role of Detection and Treatment of Liver Cancer Stem Cells in Hepatocellular Carcinoma;
      2011, (University of Kentucky CCTS) 

    NIH Participation

    • The Transplant Navigator Project 

    SPORE Collaborations

    • Role of HCV on hepatocellular homeostasis and development of liver cancer (UNC)