SPORE: Core B: Biospecimen Procurement and Analysis Core (Biospecimen Core)
Core CO-Directors: PULLIAM, Joseph, CIBULL, Michael and LEE, Eun
The Biospecimen Procurement and Analysis Core (Biospecimen Core) procures and distributes biospecimens and provides expertise and support for the investigators of the University of Kentucky (UK) Gl SPORE to perform specialized histopathologic, immunohistochemical and molecular analyses. The use of both neoplastic and non-neoplastic human and animal tissues is a key component of translational, population-based and basic science research. The goals of the Biospecimen Core are to provide formalin-fixed paraffin-embedded (FFPE) tissues, frozen tissue, blood, urine and toenail specimens, and histopathological and immunohistochemistry expertise for the GI translational studies related to the aims of the research projects comprising this SPORE proposal. To meet these goals, the following Specific Aims are proposed: 1) to provide quality-controlled human tissue biospecimens necessary for all GI cancer translational research studies, including both frozen and FFPE tissues, annotated with clinical follow-up and outcomes; 2) to provide expert pathological review for all clinical specimens utilized in the SPORE projects and to provide specific histopathological technical services as necessary for analysis of all clinical and animal tissues; and 3) to coordinate and facilitate acquisition and quality control of tissue samples from the Markey Cancer Center (MCC) affiliate hospitals required for the population-based studies in Appalachian Kentucky. The Biospecimen Core will leverage the existing resources within the MCC, the UK Department of Pathology and Laboratory Medicine, the MCC Clinical Research Coordinating Center and the Kentucky Cancer Registry, thus assuring that this core will benefit from previous efforts and techniques and that funds will be used efficiently without reproducing existing facilities.