Selected BB SRF publications, 2010-2013


1.          Arnold SM, Rinehart JJ, Tsakalozou E, Eckardt JR, Fields SZ, Shelton BJ, DeSimone PA, Kee BK, Moscow JA and Leggas M. A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies. Clin Cancer Res 16(2): 673-680, 2010. 

2.          Chen L, Lin DY and Zeng DL. Attributable fraction functions for censored event times. Biometrika 97(3): 713-726, 2010. 

3.          Feng H, Guo L, Song Z, Gao H, Wang D, Fu W, Han J, Li Z, Huang B and Li X-A. Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis. Journal of Biological Chemistry 285(33): 25154-25160, 2010. 

4.          Gal TJ, Shinn J and Huang B. Current epidemiology and management trends in acoustic neuroma. Otolaryngol Head Neck Surg 142(5): 677-681, 2010. 

5.          Gregory KJ, Zhao B, Bielenberg DR, Dridi S, Wu J, Jiang W, Huang B, Pirie-Shepherd S and Fannon M. Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prostate cancer cells. PLoS One 5(10): e13428, 2010. 

6.          Hade EM, Murray DM, Pennell ML, Rhoda D, Paskett ED, Champion VL, Crabtree BF, Dietrich A, Dignan MB, Farmer M, Fenton JJ, Flocke S, Hiatt RA, Hudson SV, Mitchell M, Monahan P, Shariff-Marco S, Slone SL, Stange K, Stewart SL and Strickland PA. Intraclass correlation estimates for cancer screening outcomes: estimates and applications in the design of group-randomized cancer screening studies. J Natl Cancer Inst Monogr 2010(40): 97-103, 2010. 

7.          Hudspeth MP, Hill TN, Lewis JA, Van Meter E and Ragucci D. Post-hematopoietic stem cell transplant immunization practices in the Pediatric Blood and Marrow Transplant Consortium. Pediatr Blood Cancer 54(7): 970-975, 2010. 

8.          Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, Weiss HL and Evers BM. Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. J Am Coll Surg 210(5): 767-776, 776-768, 2010. 

9.          Van Meter E, Lawson A, Colabianchi N, Nichols M, Hibbert J, Porter D and Liese A. An evaluation of edge effects in nutritional accessibility and availability measures: a simulation study. International Journal of Health Geographics 9(1): 40, 2010. 

10.       Vanderpool RC and Huang B. Cancer risk perceptions, beliefs, and physician avoidance in Appalachia: results from the 2008 HINTS Survey. J Health Commun 15 Suppl 3: 78-91, 2010. 

11.       Waterstrat A, Liang Y, Swiderski CF, Shelton BJ and Van Zant G. Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood 115(2): 408-417, 2010. 


12.       Christian WJ, Huang B, Rinehart J and Hopenhayn C. Exploring geographic variation in lung cancer incidence in Kentucky using a spatial scan statistic: elevated risk in the Appalachian coal-mining region. Public Health Rep 126(6): 789-796, 2011. 

13.       Dragun AE, Huang B, Tucker TC and Spanos WJ. Disparities in the application of adjuvant radiotherapy after breast-conserving surgery for early stage breast cancer: impact on overall survival. Cancer 117(12): 2590-2598, 2011. 

14.       Fleming ST, Sabatino SA, Kimmick G, Cress R, Wu X-C, Trentham-Dietz A, Huang B, Hwang W and Liff J. Developing a Claim-based Version of the ACE-27 Comorbidity Index: A Comparison With Medical Record Review. Medical Care 49(8): 752-760 2011

15.       Gal TJ, Silver N and Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 121(9): 2026-2033, 2011. 

16.       Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T and Evers BM. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71(9): 3246-3256, 2011. 

17.       Johnson N, Shelton BJ, Hopenhayn C, Tucker TT, Unrine JM, Huang B, Christian W, Zhang Z, Shi X and Li L. Concentrations of arsenic, chromium, and nickel in toenail samples from Appalachian Kentucky residents. J Environ Pathol Toxicol Oncol 30(3): 213-223, 2011. 

18.       Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM, Jr., Gao T and Evers BM. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am J Physiol Cell Physiol 301(1): C213-226, 2011. 

19.       Lutz CT, Karapetyan A, Al-Attar A, Shelton BJ, Holt KJ, Tucker JH and Presnell SR. Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol 186(8): 4590-4598, 2011. 

20.       Massarweh S, Tham YL, Huang J, Sexton K, Weiss H, Tsimelzon A, Beyer A, Rimawi M, Cai WY, Hilsenbeck S, Fuqua S and Elledge R. A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer. Breast Cancer Res Treat 129(3): 819-827, 2011. 

21.       Silva SR, Bowen KA, Rychahou PG, Jackson LN, Weiss HL, Lee EY, Townsend CM, Jr. and Evers BM. VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int J Cancer 128(5): 1045-1056, 2011. 

22.       Silva SR, Zaytseva YY, Jackson LN, Lee EY, Weiss HL, Bowen KA, Townsend CM, Jr. and Evers BM. The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON. Anticancer Res 31(4): 1153-1160, 2011. 

23.       Stults D, Killen M, Shelton B and Pierce A. Recombination phenotypes of the NCI-60 collection of human cancer cells. BMC Molecular Biology 12(1): 23, 2011. 

24.       Van Meter E, Lawson AB, Colabianchi N, Nichols M, Hibbert J, Porter D and Liese AD. Spatial accessibility and availability measures and statistical properties in the food environment. Spatial and Spatio-temporal Epidemiology 2(1): 35-47, 2011. 

25.       van Nagell JRJ, Miller RW, DeSimone CP, Ueland FR, Podzielinski I, Goodrich ST, Elder JW, Huang B, Kryscio RJ and Pavlik EJ. Long-Term Survival of Women With Epithelial Ovarian Cancer Detected by Ultrasonographic Screening. Obstetrics & Gynecology 118(6): 1212-1221, 2011. 

26.       Wang C, Tan ZQ and Louis TA. Exponential tilt models for two-group comparison with censored data. Journal of Statistical Planning and Inference 141(3): 1102-1117, 2011. 

27.       Wang Q, Zhou Y, Weiss HL, Chow CW and Evers BM. NFATc1 regulation of TRAIL expression in human intestinal cells. PLoS One 6(5): e19882, 2011. 

28.       Wang X, Gulhati P, Li J, Dobner PR, Weiss H, Townsend CM, Jr. and Evers BM. Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene. J Biol Chem 286(1): 542-554, 2011. 

29.       Zhang Z, Wang X, Cheng S, Sun L, Son YO, Yao H, Li W, Budhraja A, Li L, Shelton BJ, Tucker T, Arnold SM and Shi X. Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/beta-catenin pathway in human colorectal adenocarcinoma DLD1 cells. Toxicol Appl Pharmacol 256(2): 114-121, 2011. 

30.       Zhao Y, Burikhanov R, Brandon J, Qiu S, Shelton BJ, Spear B, Bondada S, Bryson S and Rangnekar VM. Systemic Par-4 inhibits non-autochthonous tumor growth. Cancer Biol Ther 12(2): 152-157, 2011. 


31.       Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK and Butterfield DA. Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B. Antioxid Redox Signal, 2012. 

32.       Chen L, Lin DY and Zeng DL. Checking semiparametric transformation models with censored data. Biostatistics 13(1): 18-31, 2012. 

33.       Chen L, Lin DY and Zeng DL. Predictive accuracy of covariates for event times. Biometrika 99(3): 615-630, 2012. 

34.       Dong C, Wu Y, Wang Y, Wang C, Kang T, Rychahou PG, Chi YI, Evers BM and Zhou BP. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene, 2012. 

35.       Dong L, Kudrimoti M, Cheng R, Shang Y, Johnson EL, Stevens SD, Shelton BJ and Yu G. Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery. Biomed Opt Express 3(2): 259-272, 2012. 

36.       Dragun AE, Huang B, Gupta S, Crew JB and Tucker TC. One decade later: trends and disparities in the application of post-mastectomy radiotherapy since the release of the American Society of Clinical Oncology clinical practice guidelines. Int J Radiat Oncol Biol Phys 83(5): e591-596, 2012. 

37.       Dragun AE, Huang B, Tucker TC and Spanos WJ. Increasing mastectomy rates among all age groups for early stage breast cancer: a 10-year study of surgical choice. Breast J 18(4): 318-325, 2012. 

38.       Freeman AB, Huang B and Dragun AE. Patterns of care with regard to surgical choice and application of adjuvant radiation therapy for preinvasive and early stage breast cancer in rural Appalachia. Am J Clin Oncol 35(4): 358-363, 2012. 

39.       Ganguly SS, Fiore LS, Sims JT, Friend JW, Srinivasan D, Thacker MA, Cibull ML, Wang C, Novak M, Kaetzel DM and Plattner R. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Oncogene 31(14): 1804-1816, 2012. 

40.       Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T and Evers BM. Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA. Carcinogenesis 33(9): 1782-1790, 2012. 

41.       Hebbar N, Wang C and Rangnekar VM. Mechanisms of apoptosis by the tumor suppressor Par-4. J Cell Physiol 227(12): 3715-3721, 2012. 

42.       Li J, Song J, Cassidy MG, Rychahou P, Starr ME, Liu J, Li X, Epperly G, Weiss HL, Townsend CM, Jr., Gao T and Evers BM. PI3K p110alpha/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Mol Endocrinol 26(8): 1380-1393, 2012. 

43.       Scott TL, Christian PA, Kesler MV, Donohue KM, Shelton B, Wakamatsu K, Ito S and D'Orazio J. Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation. Experimental Dermatology 21(10): 771-777, 2012. 

44.       Studts CR, Tarasenko YN, Schoenberg NE, Shelton BJ, Hatcher-Keller J and Dignan MB. A community-based randomized trial of a faith-placed intervention to reduce cervical cancer burden in Appalachia. Prev Med 54(6): 408-414, 2012. 

45.       Valentino JD, Elliott VA, Zaytseva YY, Rychahou PG, Mustain WC, Wang C, Gao T and Evers BM. Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer. Surgery 152(2): 277-285, 2012. 

46.       Van Meter EM, Garrett-Mayer E and Bandyopadhyay D. Dose-finding clinical trial design for ordinal toxicity grades using the continuation ratio model: an extension of the continual reassessment method. Clin Trials 9(3): 303-313, 2012. 

47.       Wang C, Parmigiani G and Dominici F. Bayesian Effect Estimation Accounting for Adjustment Uncertainty. Biometrics, 2012. 

48.       Wang X, Mandal AK, Saito H, Pulliam JF, Lee EY, Ke ZJ, Lu J, Ding S, Li L, Shelton BJ, Tucker T, Evers BM, Zhang Z and Shi X. Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/beta-catenin signaling pathway. Toxicol Appl Pharmacol 262(1): 11-21, 2012. 

49.       Wu H, Wang C and Wu Z. A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data. Biostatistics, 2012. 

50.       Wu X-C, Lund MJ, Kimmick GG, Richardson LC, Sabatino SA, Chen VW, Fleming ST, Morris CR, Huang B, Trentham-Dietz A and Lipscomb J. Influence of Race, Insurance, Socioeconomic Status, and Hospital Type on Receipt of Guideline-Concordant Adjuvant Systemic Therapy for Locoregional Breast Cancers. Journal of Clinical Oncology 30(2): 142-150, 2012. 

51.       Xiong G, Wang C, Evers BM, Zhou BP and Xu R. RORalpha suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Res 72(7): 1728-1739, 2012. 

52.       Yu T, Chen X, Zhang W, Colon D, Shi J, Napier D, Rychahou P, Lu W, Lee EY, Weiss HL, Evers BM and Liu C. Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer. J Biol Chem 287(6): 3760-3768, 2012. 

53.       Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY and Evers BM. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res 72(6): 1504-1517, 2012. 

54.       Zhou Y, Wang Q, Guo Z, Weiss HL and Evers BM. Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells. Molecular Biology of the Cell 23(15): 2963-2972, 2012. 


55.     Dignan M, Shelton B, Slone SA, Tolle C, Mohammad S, Schoenberg N, Pearce K, Van Meter E and Ely G. Effectiveness of a primary care practice intervention for increasing colorectal cancer screening in Appalachian Kentucky. Prev Med, 2013.

56.     Dong C, Wu Y, Wang Y, Wang C, Kang T, Rychahou PG, Chi YI, Evers BM and Zhou BP. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene 32(11): 1351-1362, 2013.

57.     Fiore LS, Ganguly SS, Sledziona J, Cibull ML, Wang C, Richards DL, Neltner JM, Beach C, McCorkle JR, Kaetzel DM and Plattner R. c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer. Oncogene, 2013.

58.     Gleason JF, Jr., Kudrimoti M, Van Meter EM, Mohiuddin M, Regine WF, Valentino J, Kenady D and Arnold SM. Low-dose fractionated radiation with induction chemotherapy for locally advanced head and neck cancer: 5 year results of a prospective phase II trial. Journal of Radiation Oncology 2(1): 35-42, 2013.

59.     Hollis CP, Weiss HL, Evers BM, Gemeinhart RA and Li T. In Vivo Investigation of Hybrid Paclitaxel Nanocrystals with Dual Fluorescent Probes for Cancer Theranostics. Pharm Res, 2013.

60.     Hollis CP, Weiss HL, Leggas M, Evers BM, Gemeinhart RA and Li T. Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery. J Control Release 172(1): 12-21, 2013.

61.     Kim JT, Li J, Jang ER, Gulhati P, Rychahou PG, Napier DL, Wang C, Weiss HL, Lee EY, Anthony L, Townsend CM, Jr., Liu C and Evers BM. Deregulation of Wnt/beta-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors. Carcinogenesis 34(5): 953-961, 2013.

62.     Narayanasamy G, Smith A, Van Meter E, McGarry R and Molloy JA. Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions. Med Phys 40(9): 091714, 2013.

63.     Rinehart J, Arnold S, Kloecker G, Lim A, Zaydan MA, Baeker T, Maheshwari JG, Carloss H, Slone S, Shelton B, Croley J, Kvale E, Brooks M and Leggas M. Phase II randomized trial of carboplatin and gemcitabine with or without dexamethasone pre-treatment in patients with Stage IV non-small cell lung cancer. Cancer Chemother Pharmacol 71(5): 1375-1383, 2013.

64.     Shang Y, Lin Y, Henry BA, Cheng R, Huang C, Chen L, Shelton BJ, Swartz KR, Salles SS and Yu G. Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator. J Biomed Opt 18(10): 105002, 2013.

65.     Shang Y, Lin Y, Henry BA, Cheng R, Huang C, Chen L, Shelton BJ, Swartz KR, Salles SS and Yu G. Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator. J Biomed Opt 18(10): 105002, 2013.

66.     Slone S, White C, Shelton B, Van Meter E, DeSimone C, Schoenberg N and Dignan M. Inconsistencies between medical records and patient-reported recommendations for follow-up after abnormal Pap tests. J Womens Health (Larchmt) 22(2): 147-152, 2013.

67.     Sui X, Li H, Zhang J, Chen L, Zhu L and Blair SN. Percentage of deaths attributable to poor cardiovascular health lifestyle factors: Findings from the Aerobics Center Longitudinal Study. Epidemiol Res Int 2013, 2013.

68.     Vanderford NL, Weiss LT and Weiss HL. A survey of the barriers associated with academic-based cancer research commercialization. PLoS One 8(8): e72268, 2013.

69.     Wang Q, Zhou Y, Rychahou P, Liu C, Weiss HL and Evers BM. NFAT5 represses canonical Wnt signaling via inhibition of beta-catenin acetylation and participates in regulating intestinal cell differentiation. Cell Death Dis 4: e671, 2013.

70.     Wu H, Wang C and Wu Z. A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data. Biostatistics 14(2): 232-243, 2013.

71.     Wu Y, Wang Y, Yang XH, Kang T, Zhao Y, Wang C, Evers BM and Zhou BP. The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells. Cell Rep 5(1): 224-236, 2013.

Accepted (9 in press) 

72.     Brooks SE, Hembree TM, Shelton BJ, Beache SC, Aschbacher G and Dignan MB. Mobile Mammography in Underserved Populations: Analysis of Outcomes of 3,923 Women. Journal of Community Health, accepted.

73.     Dignan MB, Shelton B, Slone S, Tolle C, Mohammad S, Schoenberg N, Pearce K, Van Meter E and Ely G. Effectiveness of a Primary Care Practice Intervention for Increasing Colorectal Cancer Screening in Appalachian Kentucky. Journal of Preventative Medicine, accepted.

74.     Dignan MB, White C, Schoenberg N, Shelton B, Feltner F, Slone S, Van Meter E, DeSimone C and Ely G. Effectiveness of a Patient Navigation Intervention to Increase Adherence to Follow-Up Recommendations for Women with Abnormal Pap Tests in Appalachian Kentucky. Journal of Health Behavior & Policy Review, accepted.

75.     Ely GE, White C, Feltner F, Gomez M, Shelton B, Slone S, Van Meter E, DeSimone C, Schoenberg N and Dignan M. Cervical Cancer Screening: Exploring Appalachian Patients’ Barriers to Follow Up Care. Social Work in Health Care, accepted.

76.     Feddock J, Sinha P, Conrad G, Shelton BJ, Chen L, Arnold SM, Rinehart J and McGarry RC. Risk for Fatal Pulmonary Hemorrhage does not appear to be increased following dose escalation using Stereotactic Body Radiotherapy (SBRT) in Locally Advanced Non-Small Cell Lung Cancer. Journal of Radiosurgery and SBRT, accepted.

77.     Lian H, Lin Y, Shang Y, Shelton BJ and Yu G. Using Optical Fibers with Different Modes to Improve the Signal-to-Noise Ratio of DCS Flow-Oximeter Measurement. Journal of Biomedical Optics, accepted.

78.     Massarweh S, Romond E, Black EP, Van Meter E, Shelton BJ, Karamyan-Melkumian V, Stevens M and Elledge R. A Phase II study of combined fulvestrant and everolimus in patients with metastatic estrogen receptor (ER)-positive breast cancer after aromatase inhibitor failure. Breast Cancer Treatment and Research, accepted.

79.     McGarry RC, Feddock J, Sinha P, Conrad G, Shelton BJ, Chen L, Arnold SM and Rinehart J. Early Postchemoradiation PET/CT for Assessing Treatment Responses of Stage II-III Non-Small Cell Lung Cancer for SBRT Boost. Journal of Radiosurgery and SBRT, accepted.

80.     Mustain WC, Starr ME, Valentino J, Cohen DA, Okamura D, Wang C, Evers BM and Saito H. Inflammatory cytokine gene expression in mesenteric adipose adipose tissue during acute experimental colitis. PLoS One, accepted.




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