Stephen J. Ryan, MD

Director, EEG Lab

Clinical interests

  • Clinical Neurophysiology
  • Electroencephalography
  • Electromyography
  • Myasthenia Gravis
  • Myopathy
  • Neuromuscular Disease
  • Neuropathies
  • Quantitative Sensory Testing
  • Stroke

Stephen J. Ryan, MD

Director, EEG Lab

Biography

My name is Stephen J. Ryan; I received my medical degree from the University of Missouri Columbia School of Medicine, Columbia. I then completed a fellowship at the University of Kentucky, Lexington.

I am board certified by the American Board of Psychiatry and Neurology in Clinical Neurophysiology and Neuromusclar Medicine.

Faculty rank

Professor of Neurology

Education

Degree
University of Missouri Columbia School of Medicine, Columbia

Residency
University of Kentucky, Lexington

Fellowship
University of Kentucky, Lexington

Certifications or Special training
American Board of Psychiatry and Neurology
American Board of Psychiatry and Neurology, Neuromuscular Medicine
American Board of Psychiatry and Neurology, Clinical Neurophysiology

Neurology

Kentucky Neuroscience Institute

Kentucky Clinic
First Floor, Wing C, Room B101
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-5661
Fax 859-323-3753

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

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  1. Gadient PM, Smith JH, Ryan SJ. Herpes zoster ophthalmicus following onabotulinumtoxinA administration for chronic migraine: a case report and literature review. Cephalalgia. 2015 Apr;35(5):443-8
    View in: PubMed
  2. Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1; 53(5):1111-22. PMID: 22781655.
    View in: PubMed
  3. Ryan SJ. Interview with Stephen J. Ryan, MD, by George B. Bartley, MD. Arch Ophthalmol. 2012 May 1; 130(5):650-1. PMID: 22652853.
    View in: PubMed
  4. Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton DR. Mechanism of RPE cell death in a-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS One. 2012; 7(3):e33420. PMID: 22442691.
    View in: PubMed
  5. Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton DR. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. PMID: 22392094.
    View in: PubMed
  6. Khankan R, Oliver N, He S, Ryan SJ, Hinton DR. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5068-78. PMID: 21571675.
    View in: PubMed
  7. Shang Y, Cheng R, Dong L, Ryan SJ, Saha SP, Yu G. Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram. Phys Med Biol. 2011 May 21; 56(10):3015-32. PMID: 21508444.
    View in: PubMed
  8. Ryan SJ. With looming budget cuts, vision research advocacy is vital. Optom Vis Sci. 2011 Apr; 88(4):454-5. PMID: 21430501.
    View in: PubMed
  9. Xu J, Zhu D, He S, Spee C, Ryan SJ, Hinton DR. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J. 2011 Jul; 25(7):2221-33. PMID: 21411747.
    View in: PubMed
  10. Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR. aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010; 5(10):e12578. PMID: 20949024.
    View in: PubMed
  11. Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton DR. Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. PMID: 20204129.
    View in: PubMed
  12. Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton DR. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2010; 2(1):28-42. PMID: 20228934.
    View in: PubMed
  13. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. PMID: 20023214.
    View in: PubMed
  14. He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. PMID: 19696168.
    View in: PubMed
  15. Kim YH, He S, Kase S, Kitamura M, Ryan SJ, Hinton DR. Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol. 2009 May; 247(5):651-9. PMID: 19214553.
    View in: PubMed
  16. Zhu D, Wu J, Spee C, Ryan SJ, Hinton DR. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem. 2009 Apr 3; 284(14):9529-39. PMID: 19158083.
    View in: PubMed
  17. Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009; 4(5):662-73. PMID: 19373231.
    View in: PubMed
  18. Sreekumar PG, Ding Y, Ryan SJ, Kannan R, Hinton DR. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res. 2009 Mar; 88(3):410-7. PMID: 18996115.
    View in: PubMed
  19. Jones N, Hardes G, Ryan S, Sheehan J, Cox C, Meleady K, Jayasinha H. Projected acute inpatient activity in New South Wales - aIM2005. Aust Health Rev. 2008 Aug; 32(3):528-36. PMID: 18666882.
    View in: PubMed
  20. Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, Barthorpe S, Buck G, Cole J, Halliday K, Jones D, Lee R, Madison M, Mironenko T, Varian J, West S, Widaa S, Wray P, Teague J, Dicks E, Butler A, Menzies A, Jenkinson A, Shepherd R, Gusella JF, Afawi Z, Mazarib A, Neufeld MY, Kivity S, Lev D, Lerman-Sagie T, Korczyn AD, Derry CP, Sutherland GR, Friend K, Shaw M, Corbett M, Kim HG, Geschwind DH, Thomas P, Haan E, Ryan S, McKee S, Berkovic SF, Futreal PA, Stratton MR, Mulley JC, Gécz J. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet. 2008 Jun; 40(6):776-81. PMID: 18469813.
    View in: PubMed
  21. He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR. Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4078-88. PMID: 18450591.
    View in: PubMed
  22. Vaishnav AG, Pettigrew LC, Ryan S. Telephonic guidance of systemic thrombolysis in acute ischemic stroke: safety outcome in rural hospitals. Clin Neurol Neurosurg. 2008 May; 110(5):451-4. PMID: 18353532.
    View in: PubMed
  23. Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1210-20. PMID: 18326751.
    View in: PubMed
  24. He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR. Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2008 May; 246(5):677-83. PMID: 18278507.
    View in: PubMed
  25. Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton DR. In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. PMID: 17401340.
    View in: PubMed
  26. He S, Incardona F, Jin M, Ryan SJ, Hinton DR. Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. PMID: 17378161.
    View in: PubMed
  27. Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. PMID: 16793007.
    View in: PubMed
  28. Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR. MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006 Apr; 26(4):454-61. PMID: 16603966.
    View in: PubMed
  29. Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. PMID: 16563380.
    View in: PubMed
  30. Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
    View in: PubMed
  31. He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. PMID: 16303978.
    View in: PubMed
  32. Ryan SJ. National and international patient networks: standardization of phenotype and genotype definitions. Retina. 2005 Dec; 25(8 Suppl):S68. PMID: 16374345.
    View in: PubMed
  33. Ryan SJ. Governmental, university, pharmaceutical, and foundation partnerships to advance translational research in retinal disease. Retina. 2005 Dec; 25(8 Suppl):S82. PMID: 16374353.
    View in: PubMed
  34. Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton DR. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. PMID: 16376649.
    View in: PubMed
  35. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. PMID: 16288810.
    View in: PubMed
  36. Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. PMID: 16249513.
    View in: PubMed
  37. Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton DR. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. PMID: 15993845.
    View in: PubMed
  38. Hoffmann S, Balthasar S, Friedrichs U, Ehren M, Ryan SJ, Wiedemann P. Inhibitory effects of verapamil isomers on the proliferation of choroidal endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2006 Mar; 244(3):376-81. PMID: 16088412.
    View in: PubMed
  39. Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton DR. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005; 5:16. PMID: 15987521.
    View in: PubMed
  40. Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton DR. Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005; 11:414-24. PMID: 15988410.
    View in: PubMed
  41. Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. PMID: 15856049.
    View in: PubMed
  42. Hoffmann S, He S, Jin ML, Masiero L, Wiedemann P, Ryan SJ, Kohn EC. Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells. Curr Eye Res. 2005 Feb; 30(2):103-13. PMID: 15814468.
    View in: PubMed
  43. Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton DR. Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. PMID: 14744883.
    View in: PubMed
  44. Jin M, Chen Y, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):323-9. PMID: 14691191.
    View in: PubMed
  45. Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol. 2002 Oct; 161(4):1429-37. PMID: 12368215.
    View in: PubMed
  46. Jin M, Barron E, He S, Ryan SJ, Hinton DR. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2782-90. PMID: 12147616.
    View in: PubMed
  47. Ryan SJ, Hinton DR, Ogden TE, Rao N. Translational research in ophthalmology. Arch Ophthalmol. 2002 Mar; 120(3):389-90. PMID: 11879146.
    View in: PubMed
  48. Smith CD, Ryan SJ, Hoover SL, Baumann RJ. Magnetic resonance imaging of the brain in Aicardi's syndrome. Report of 20 patients. J Neuroimaging. 1996 Oct; 6(4):214-21. PMID: 8903072.
    View in: PubMed
  49. Ryan SJ. The illness of Saint Fina. J Child Neurol. 1996 May; 11(3):258. PMID: 8734038.
    View in: PubMed
  50. Ryan SJ, Pettigrew LC. Cranial arteriopathy in familial Vogt-Koyanagi-Harada syndrome. J Neuroimaging. 1995 Oct; 5(4):244-5. PMID: 7579754.
    View in: PubMed
  51. Ryan SJ, Smith CD, Slevin JT. Magnetic resonance imaging in ochronosis, a rare cause of back pain. J Neuroimaging. 1994 Jan; 4(1):41-2. PMID: 8136578.
    View in: PubMed
  52. Ryan SJ. De novo subretinal neovascularization in the histoplasmosis syndrome. Arch Ophthalmol. 1976 Feb; 94(2):321-7. PMID: 1252182.
    View in: PubMed
  53. Michels RG, Ryan SJ. Results and complications of 100 consecutive cases of pars plana vitrectomy. Am J Ophthalmol. 1975 Jul; 80(1):24-9. PMID: 1155545.
    View in: PubMed
  54. Ryan SJ, Knox DL, Green WR, Konigsmark BW. Olivopontocerebellar degeneration. Clinicopathologic correlation of the associated retinopathy. Arch Ophthalmol. 1975 Mar; 93(3):169-72. PMID: 1138681.
    View in: PubMed
  55. Ryan SJ. Occlusion of the macular capillaries in sickle cell hemoglobin C disease. Am J Ophthalmol. 1974 Apr; 77(4):459-61. PMID: 4819448.
    View in: PubMed
  56. Ryan SJ. Cystoid maculopathy in phakic retinal detachment procedures. Am J Ophthalmol. 1973 Oct; 76(4):519-22. PMID: 4743807.
    View in: PubMed
  57. Frank RN, Ryan SJ. Peripheral retinal neovascularization with chronic myelogenous leukemia. Arch Ophthalmol. 1972 May; 87(5):585-9. PMID: 4503298.
    View in: PubMed
  58. Ryan SJ, Frank RN, Green WR. Bilateral inflammatory pseudotumors of the ciliary body. Am J Ophthalmol. 1971 Sep; 72(3):586-91. PMID: 5568609.
    View in: PubMed