Kenneth B. Ain, MD

Clinical interests

  • Endocrinology
  • Thyroid Cancer
  • Thyroid Disease

Kenneth B. Ain, MD

Biography

My name is Kenneth Ain; I received my medical degree from The Warren Alpert Medical School of Brown University, Providence, R.I. I then completed fellowships at National Institute of Health, Bethesda, Md. and the University of Chicago Hospital and Clinics.

I am board certified by the American Board of Internal Medicine in Endocrinology and Metabolism.

Faculty rank

Professor of Medicine

Education

Degree
The Warren Alpert Medical School of Brown University, Providence, R.I. 

Residency
Hahnemann University Hospital, Philadelphia

Fellowship
National Institute of Health, Bethesda, Md.
University of Chicago Hospital and Clinics, Chicago

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Endocrinology and Metabolism

Endocrine Cancer

Kentucky Clinic
Second Floor
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-3778
Fax 866-340-4488

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

Kentucky Clinic Map (PDF, 616 KB) »
Directions to Kentucky Clinic Parking »



Endocrinology

Medicine Specialties

Kentucky Clinic
Second Floor, Wing C
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-2232
Fax 859-257-2634

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

Kentucky Clinic Map (PDF, 616 KB) »
Directions to Kentucky Clinic Parking »


UK HealthCare accepts many forms of insurance. See list of insurers »

 
  1. McLeod DS, Jonklaas J, Brierley JD, Ain KB, Cooper DS, Fein HG, Haugen BR, Ladenson PW, Magner J, Ross DS, Skarulis MC, Steward DL, Xing M, Litofsky DR, Maxon HR, Sherman SI. Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis. Thyroid. 2015 Oct;25(10):1097-105.
    View in: PubMed
  2. Ain KB. Radioiodine-remnant ablation in low-risk differentiated thyroid cancer: pros. Endocrine. 2015 Sep;50(1):61-6.
    View in: PubMed
  3. Carhill AA, Litofsky DR, Ross DS, Jonklaas J, Cooper DS, Brierley JD, Ladenson PW, Ain KB, Fein HG, Haugen BR, Magner J, Skarulis MC, Steward DL, Xing M, Maxon HR, Sherman SI. Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987-2012. J Clin Endocrinol Metab. 2015 Sep;100(9):3270-9.
    View in: PubMed
  4. Smith CD, Grondin R, LeMaster W, Martin B, Gold BT, Ain KB. Reversible cognitive, motor, and driving impairments in severe hypothyroidism. Thyroid. 2015 Jan;25(1):28-36.
    View in: PubMed
  5. Gal TJ, Streeter M, Burris J, Kudrimoti M, Ain KB, Valentino J. Quality of life impact of external beam radiotherapy for advanced thyroid carcinoma. Thyroid. 2013 Jan; 23(1):64-9. PMID: 22971127.
    View in: PubMed
  6. Smallridge RC, Ain KB, Asa SL, Bible KC, Brierley JD, Burman KD, Kebebew E, Lee NY, Nikiforov YE, Rosenthal MS, Shah MH, Shaha AR, Tuttle For The American Thyroid Association Anaplastic Thyroid Cancer Guidelines Taskforce RM. American thyroid association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2012 Nov; 22(11):1104-39. PMID: 23130564.
    View in: PubMed
  7. Jonklaas J, Nogueras-Gonzalez G, Munsell M, Litofsky D, Ain KB, Bigos ST, Brierley JD, Cooper DS, Haugen BR, Ladenson PW, Magner J, Robbins J, Ross DS, Skarulis MC, Steward DL, Maxon HR, Sherman SI. The impact of age and gender on papillary thyroid cancer survival. J Clin Endocrinol Metab. 2012 Jun; 97(6):E878-87. PMID: 22496497.
    View in: PubMed
  8. Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B. Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. J Nat Prod. 2012 Mar 23; 75(3):385-93. PMID: 22324723.
    View in: PubMed
  9. Alapat DV, Ain KB, Sloan DA, Monaghan KG, Karabakhtsian RG. Disparity between tissue and serum calcitonin and carcinoembryonic antigen in a patient with medullary thyroid carcinoma. Endocrine. 2011 Apr; 39(2):148-52. PMID: 21243446.
    View in: PubMed
  10. Jonklaas J, Cooper DS, Ain KB, Bigos T, Brierley JD, Haugen BR, Ladenson PW, Magner J, Ross DS, Skarulis MC, Steward DL, Maxon HR, Sherman SI. Radioiodine therapy in patients with stage I differentiated thyroid cancer. Thyroid. 2010 Dec; 20(12):1423-4. PMID: 21054207.
    View in: PubMed
  11. Li W, Ain KB. Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells. Endocr Relat Cancer. 2010 Jun; 17(2):383-98. PMID: 20228127.
    View in: PubMed
  12. Ross DS, Litofsky D, Ain KB, Bigos T, Brierley JD, Cooper DS, Haugen BR, Jonklaas J, Ladenson PW, Magner J, Robbins J, Skarulis MC, Steward DL, Maxon HR, Sherman SI. Recurrence after treatment of micropapillary thyroid cancer. Thyroid. 2009 Oct; 19(10):1043-8. PMID: 19772419.
    View in: PubMed
  13. Ain KB, Lee C, Williams KD. Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas. Thyroid. 2007 Jul; 17(7):663-70. PMID: 17696837.
    View in: PubMed
  14. Li W, Venkataraman GM, Ain KB. Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in human thyroid adenoma cell line, KAK-1, suggesting trans-active transcriptional repressor. J Clin Endocrinol Metab. 2007 Mar; 92(3):1080-7. PMID: 17164311.
    View in: PubMed
  15. Jonklaas J, Sarlis NJ, Litofsky D, Ain KB, Bigos ST, Brierley JD, Cooper DS, Haugen BR, Ladenson PW, Magner J, Robbins J, Ross DS, Skarulis M, Maxon HR, Sherman SI. Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid. 2006 Dec; 16(12):1229-42. PMID: 17199433.
    View in: PubMed
  16. Mitsiades CS, McMillin D, Kotoula V, Poulaki V, McMullan C, Negri J, Fanourakis G, Tseleni-Balafouta S, Ain KB, Mitsiades N. Antitumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro. J Clin Endocrinol Metab. 2006 Oct; 91(10):4013-21. PMID: 16849420.
    View in: PubMed
  17. Dziba JM, Ain KB. Imatinib mesylate (gleevec; STI571) monotherapy is ineffective in suppressing human anaplastic thyroid carcinoma cell growth in vitro. J Clin Endocrinol Metab. 2004 May; 89(5):2127-35. PMID: 15126530.
    View in: PubMed
  18. Whitley RJ, Ain KB. Thyroglobulin: a specific serum marker for the management of thyroid carcinoma. Clin Lab Med. 2004 Mar; 24(1):29-47. PMID: 15157556.
    View in: PubMed
  19. Ain KB. Pathobiology of antineoplastic therapy in undifferentiated thyroid cancer. Cancer Treat Res. 2004; 122:357-67. PMID: 16209055.
    View in: PubMed
  20. Xu X, Quiros RM, Maxhimer JB, Jiang P, Marcinek R, Ain KB, Platt JL, Shen J, Gattuso P, Prinz RA. Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis. Clin Cancer Res. 2003 Dec 1; 9(16 Pt 1):5968-79. PMID: 14676122.
    View in: PubMed
  21. Xu X, Quiros RM, Gattuso P, Ain KB, Prinz RA. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res. 2003 Aug 1; 63(15):4561-7. PMID: 12907632.
    View in: PubMed
  22. Dziba JM, Marcinek R, Venkataraman G, Robinson JA, Ain KB. Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors. Thyroid. 2002 Dec; 12(12):1063-70. PMID: 12593719.
    View in: PubMed
  23. Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A, Chung JH, Giuliani C, Thornton M, Slugocki G, Tobin DJ. Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin. J Invest Dermatol. 2002 Dec; 119(6):1449-55. PMID: 12485453.
    View in: PubMed
  24. Ouyang B, Knauf JA, Ain K, Nacev B, Fagin JA. Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clin Endocrinol (Oxf). 2002 Mar; 56(3):341-50. PMID: 11940046.
    View in: PubMed
  25. Yatin SM, Yatin M, Varadarajan S, Ain KB, Butterfield DA. Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity. J Neurosci Res. 2001 Mar 1; 63(5):395-401. PMID: 11223914.
    View in: PubMed
  26. Greenberg VL, Williams JM, Boghaert E, Mendenhall M, Ain KB, Zimmer SG. Butyrate alters the expression and activity of cell cycle components in anaplastic thyroid carcinoma cells. Thyroid. 2001 Jan; 11(1):21-9. PMID: 11272092.
    View in: PubMed
  27. Ain KB. Management of undifferentiated thyroid cancer. Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Dec; 14(4):615-29. PMID: 11289738.
    View in: PubMed
  28. Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte PH, Treseler PA, Weier HU, Freimer N, Siperstein AE, Duh QY, Takami H, Clark OH. Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series. Surgery. 2000 Dec; 128(6):1043-50;discussion 1050-1. PMID: 11114641.
    View in: PubMed
  29. Ain KB, Egorin MJ, DeSimone PA. Treatment of anaplastic thyroid carcinoma with paclitaxel: phase 2 trial using ninety-six-hour infusion. Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group. Thyroid. 2000 Jul; 10(7):587-94. PMID: 10958311.
    View in: PubMed
  30. Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG, Smith SA, Daniels GH, Cohen HD. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000 Jun 12; 160(11):1573-5. PMID: 10847249.
    View in: PubMed
  31. Ain KB. Unusual types of thyroid cancer. Rev Endocr Metab Disord. 2000 Apr; 1(3):225-31. PMID: 11708297.
    View in: PubMed
  32. Bretz JD, Rymaszewski M, Arscott PL, Myc A, Ain KB, Thompson NW, Baker JR. TRAIL death pathway expression and induction in thyroid follicular cells. J Biol Chem. 1999 Aug 13; 274(33):23627-32. PMID: 10438545.
    View in: PubMed
  33. Yatin M, Venkataraman GM, Marcinek R, Ain KB. Polyamine synthesis and transport inhibition in a human anaplastic thyroid carcinoma cell line in vitro and as xenograft tumors. Thyroid. 1999 Aug; 9(8):805-14. PMID: 10482374.
    View in: PubMed
  34. Venkataraman GM, Yatin M, Marcinek R, Ain KB. Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation status. J Clin Endocrinol Metab. 1999 Jul; 84(7):2449-57. PMID: 10404820.
    View in: PubMed
  35. Yatin SM, Yatin M, Aulick T, Ain KB, Butterfield DA. Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett. 1999 Mar 19; 263(1):17-20. PMID: 10218900.
    View in: PubMed
  36. Koong SS, Reynolds JC, Movius EG, Keenan AM, Ain KB, Lakshmanan MC, Robbins J. Lithium as a potential adjuvant to 131I therapy of metastatic, well differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1999 Mar; 84(3):912-6. PMID: 10084570.
    View in: PubMed
  37. Ain KB. Anaplastic thyroid carcinoma: a therapeutic challenge. Semin Surg Oncol. 1999 Jan-Feb; 16(1):64-9. PMID: 9890741.
    View in: PubMed
  38. Taylor T, Specker B, Robbins J, Sperling M, Ho M, Ain K, Bigos ST, Brierley J, Cooper D, Haugen B, Hay I, Hertzberg V, Klein I, Klein H, Ladenson P, Nishiyama R, Ross D, Sherman S, Maxon HR. Outcome after treatment of high-risk papillary and non-Hürthle-cell follicular thyroid carcinoma. Ann Intern Med. 1998 Oct 15; 129(8):622-7. PMID: 9786809.
    View in: PubMed
  39. Sherman SI, Brierley JD, Sperling M, Ain KB, Bigos ST, Cooper DS, Haugen BR, Ho M, Klein I, Ladenson PW, Robbins J, Ross DS, Specker B, Taylor T, Maxon HR. Prospective multicenter study of thyroiscarcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer. 1998 Sep 1; 83(5):1012-21. PMID: 9731906.
    View in: PubMed
  40. Cooper DS, Specker B, Ho M, Sperling M, Ladenson PW, Ross DS, Ain KB, Bigos ST, Brierley JD, Haugen BR, Klein I, Robbins J, Sherman SI, Taylor T, Maxon HR. Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Cooperative Registry. Thyroid. 1998 Sep; 8(9):737-44. PMID: 9777742.
    View in: PubMed
  41. Ain KB. Anaplastic thyroid carcinoma: behavior, biology, and therapeutic approaches. Thyroid. 1998 Aug; 8(8):715-26. PMID: 9737368.
    View in: PubMed
  42. Aziz SM, Worthen DR, Yatin M, Ain KB, Crooks PA. A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene. Biochem Pharmacol. 1998 Jul 15; 56(2):181-7. PMID: 9698071.
    View in: PubMed
  43. Blagosklonny MV, Giannakakou P, Wojtowicz M, Romanova LY, Ain KB, Bates SE, Fojo T. Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells. J Clin Endocrinol Metab. 1998 Jul; 83(7):2516-22. PMID: 9661637.
    View in: PubMed
  44. Graff JR, Greenberg VE, Herman JG, Westra WH, Boghaert ER, Ain KB, Saji M, Zeiger MA, Zimmer SG, Baylin SB. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res. 1998 May 15; 58(10):2063-6. PMID: 9605742.
    View in: PubMed
  45. Musgrave YM, Davey DD, Weeks JA, Banks ER, Rayens MK, Ain KB. Assessment of fine-needle aspiration sampling technique in thyroid nodules. Diagn Cytopathol. 1998 Jan; 18(1):76-80. PMID: 9451563.
    View in: PubMed
  46. Venkataraman GM, Yatin M, Ain KB. Cloning of the human sodium-iodide symporter promoter and characterization in a differentiated human thyroid cell line, KAT-50. Thyroid. 1998 Jan; 8(1):63-9. PMID: 9492156.
    View in: PubMed
  47. Ain KB, Taylor KD, Tofiq S, Venkataraman G. Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines. J Clin Endocrinol Metab. 1997 Jun; 82(6):1857-62. PMID: 9177396.
    View in: PubMed
  48. Ain KB, Pucino F, Csako G, Wesley RA, Drass JA, Clark C, Ketteridge P, Crawford K, Banks SM, Dorworth TE. Effects of restricting levothyroxine dosage strength availability. Pharmacotherapy. 1996 Nov-Dec; 16(6):1103-10. PMID: 8947984.
    View in: PubMed
  49. Boghaert ER, Ain K, Taylor K, Greenberg VL, Fowler C, Zimmer SG. Quantitative and qualitative differences in growth, invasion and lung colonization of an anaplastic and a papillary human thyroid cancer cell line in vitro and in vivo. Clin Exp Metastasis. 1996 Oct; 14(5):440-50. PMID: 8871538.
    View in: PubMed
  50. Ain KB, Tofiq S, Taylor KD. Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo. J Clin Endocrinol Metab. 1996 Oct; 81(10):3650-3. PMID: 8855817.
    View in: PubMed
  51. Shih WJ, Stipp V, Magoun S, Ain KB, Pulmano C. Medullary thyroid carcinoma imaged by Tc-99m MIBI SPECT and Tl-201 chloride/Tc-99m pertechnetate subtraction SPECT. Clin Nucl Med. 1996 Mar; 21(3):213-7. PMID: 8846566.
    View in: PubMed
  52. Ain KB. Papillary thyroid carcinoma. Etiology, assessment, and therapy. Endocrinol Metab Clin North Am. 1995 Dec; 24(4):711-60. PMID: 8608778.
    View in: PubMed
  53. Pineda JD, Lee T, Ain K, Reynolds JC, Robbins J. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab. 1995 May; 80(5):1488-92. PMID: 7744991.
    View in: PubMed
  54. Smith CD, Ain KB. Brain metabolism in hypothyroidism studied with 31P magnetic-resonance spectroscopy. Lancet. 1995 Mar 11; 345(8950):619-20. PMID: 7898179.
    View in: PubMed
  55. Ain KB, Shih WJ. False-positive I-131 uptake at a tracheostomy site. Discernment with Tl-201 imaging. Clin Nucl Med. 1994 Jul; 19(7):619-21. PMID: 7924106.
    View in: PubMed
  56. Ain KB, Dewitt PA, Gardner TG, Berryman SW. Low-iodine tube-feeding diet for iodine-131 scanning and therapy. Clin Nucl Med. 1994 Jun; 19(6):504-7. PMID: 8062468.
    View in: PubMed
  57. Ain KB, Taylor KD. Somatostatin analogs affect proliferation of human thyroid carcinoma cell lines in vitro. J Clin Endocrinol Metab. 1994 May; 78(5):1097-102. PMID: 7909817.
    View in: PubMed
  58. Smith CD, Ain KB, Ryan S, Ngai BC. Systemic embolism in thyrotoxicosis without cardiac arrhythmia. Thyroid. 1994; 4(2):209-11. PMID: 7920006.
    View in: PubMed
  59. Ain KB, Pucino F, Shiver TM, Banks SM. Thyroid hormone levels affected by time of blood sampling in thyroxine-treated patients. Thyroid. 1993; 3(2):81-5. PMID: 8369656.
    View in: PubMed
  60. Ain KB, Refetoff S, Fein HG, Weintraub BD. Pseudomalabsorption of levothyroxine. JAMA. 1991 Oct 16; 266(15):2118-20. PMID: 1920700.
    View in: PubMed
  61. Robbins J, Merino MJ, Boice JD, Ron E, Ain KB, Alexander HR, Norton JA, Reynolds J. Thyroid cancer: a lethal endocrine neoplasm. Ann Intern Med. 1991 Jul 15; 115(2):133-47. PMID: 2058861.
    View in: PubMed
  62. Axiotis CA, Merino MJ, Ain K, Norton JA. Papillary endothelial hyperplasia in the thyroid following fine-needle aspiration. Arch Pathol Lab Med. 1991 Mar; 115(3):240-2. PMID: 2001162.
    View in: PubMed
  63. Sarne DH, Sobieszczyk S, Ain KB, Refetoff S. Serum thyrotropin and prolactin in the syndrome of generalized resistance to thyroid hormone: responses to thyrotropin-releasing hormone stimulation and short term triiodothyronine suppression. J Clin Endocrinol Metab. 1990 May; 70(5):1305-11. PMID: 2110573.
    View in: PubMed
  64. Sakurai A, Takeda K, Ain K, Ceccarelli P, Nakai A, Seino S, Bell GI, Refetoff S, DeGroot LJ. Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8977-81. PMID: 2510172.
    View in: PubMed
  65. Ain KB, Refetoff S. Relationship of oligosaccharide modification to the cause of serum thyroxine-binding globulin excess. J Clin Endocrinol Metab. 1988 May; 66(5):1037-43. PMID: 3129446.
    View in: PubMed
  66. Ain KB, Refetoff S, Sarne DH, Murata Y. Effect of estrogen on the synthesis and secretion of thyroxine-binding globulin by a human hepatoma cell line, Hep G2. Mol Endocrinol. 1988 Apr; 2(4):313-23. PMID: 2837662.
    View in: PubMed
  67. Ain KB, Mori Y, Refetoff S. Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration. J Clin Endocrinol Metab. 1987 Oct; 65(4):689-96. PMID: 3116030.
    View in: PubMed
  68. Ain KB, Barall DT, Perez RG, Ward HA. Patterns of automotive safety restraint use in rhode island: impact of the child passenger restraint law. R I Med J. 1981 Nov; 64(11):515-9. PMID: 6947373.
    View in: PubMed