Patrick W. O'Donnell, MD


My name is Patrick O'Donnell; I received my medical and doctorate degrees from Indiana University School of Medicine, Indianapolis. I completed a residency in orthopaedic surgery at the University of Minnesota, Minneapolis. I then completed a fellowship in musculoskeletal oncology at the University of Toronto, Mt. Sinai Hospital, Princess Margaret Cancer Center, Toronto, Ontario, Canada.

I am currently an Assistant Professor and the director of the Sarcoma Program at the University of Kentucky, Markey Cancer Center.

Personal statement

As an orthopaedic oncologist, I get to treat patients of every age. I operate on every bone in the body so I get many different surgeries, and it's made me a better surgeon. I treat many different types of cancers, including tumors that have started outside the bone and tumors that have spread inside the bone.

I help people by performing reconstructive surgery. We often help patients who have periprosthetic fractures with tumor-style prosthesis. Additionally, we are able to use many surgical techniques to help patients who don’t have cancer.

Patients that previously had no options for their hip or knee have options now. We can replace entire bones, including the femur, the biggest bone in the body. We can provide a cancer-style prosthesis that we connect with a knee replacement and a hip replacement and provide patients a new leg to walk on.

Faculty rank

Assistant Professor of Orthopaedic Surgery


Indiana University, School of Medicine, Indianapolis

University of Minnesota Medical Center, Minneapolis

University of Toronto, Mt. Sinai Hospital, Toronto, Ontario, Canada

Certifications or Special training
American Board of Orthopaedic Surgery

Bone Cancer

Multidisciplinary Clinic

Markey Cancer Center
Whitney-Hendrickson Building
First Floor
800 Rose St.
Lexington KY 40536-0098

Call 859-257-4488

A parking lot for Markey Cancer Center patients is located near the Whitney-Hendrickson Building, accessible via Hospital Drive.

Directions to Markey Cancer Center - Whitney-Hendrickson Building »

Joint Reconstruction and Replacement

UK Good Samaritan Medical Office Building
Suite 201
125 E. Maxwell St.
Lexington KY 40508-2678

Call 859-323-5533
Call 800-333-8874

Parking is available at the Good Samaritan Medical Plaza Parking Lot (on site).

Directions to UK Good Samaritan Medical Office Building Parking »

Insurance information

Insurance policies can vary widely. Please check with your doctor/clinic for specific insurance information before your visit or procedure to avoid unexpected out-of-pocket costs. See list of insurers »

Referral form for physicians »

  1. O'Donnell PW, Manivel JC, Cheng EY, Clohisy DR. Chemotherapy influences the pseudocapsule composition in soft tissue sarcomas. Clin Orthop Relat Res. 2014 Mar;472(3):849-55.
    View in: PubMed
  2. O'Donnell PW, Griffin AM, Eward WC, Sternheim A, Wunder JS, Ferguson PC. Early follow-up of a custom non-fluted diaphyseal press-fit tumour prosthesis. Int Orthop. 2014 Jan;38(1):123-7.
    View in: PubMed
  3. O'Donnell PW, Griffin AM, Eward WC, Sternheim A, White LM, Wunder JS, Ferguson PC. Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI? Sarcoma. 2013;2013:982784.
    View in: PubMed
  4. O'Donnell PW. One resident's experience designing and running a randomized control trial in orthopedic surgery. J Surg Educ. 2011 May-Jun; 68(3):250-3. PMID: 21481812.
    View in: PubMed
  5. O'Donnell PW, Anavian J, Switzer JA, Morgan RA. The history of the halo skeletal fixator. Spine (Phila Pa 1976). 2009 Jul 15; 34(16):1736-9. PMID: 19770616.
    View in: PubMed
  6. Loder RT, O'Donnell PW, Feinberg JR. Epidemiology and mechanisms of femur fractures in children. J Pediatr Orthop. 2006 Sep-Oct; 26(5):561-6. PMID: 16932091.
    View in: PubMed
  7. Loder RT, O'Donnell PW, Didelot WP, Kayes KJ. Valgus slipped capital femoral epiphysis. J Pediatr Orthop. 2006 Sep-Oct; 26(5):594-600. PMID: 16932097.
    View in: PubMed
  8. O'Donnell PW, Haque A, Klemsz MJ, Kaplan MH, Blum JS. Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent. J Immunol. 2004 Jul 15; 173(2):731-5. PMID: 15240658.
    View in: PubMed
  9. Sriram V, Cho S, Li P, O'Donnell PW, Dunn C, Hayakawa K, Blum JS, Brutkiewicz RR. Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8197-202. PMID: 12060764.
    View in: PubMed

Oncologist Patrick O’Donnell on why he has the world’s best job - July 13, 2017

Types of Bone Cancers and Ways to Treat Them Vary - May 7, 2013

A patient's story

Dr. O'Donnell and Tracy Profitt
Dr. Patrick O'Donnell and Tracy Profitt discuss a treatment plan for former UK basketball player, Todd Svoboda. Read Todd's patient story »