The end of the year is a natural time to reflect on the past and look forward to the future, and this year at Markey, that happened to coincide with a visit from our External Advisory Board (EAB) earlier this month. Our EAB serves an important purpose – their existence is mandated by our National Cancer Institute designation, and their purpose is to guide Markey toward becoming an even better NCI designated center in every way possible.
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LEXINGTON, Ky. (Jan. 21, 2015) – The University of Kentucky Markey Cancer Center will host a special gala on Saturday, Feb. 7, to support its second annual Expressions of Courage exhibit this summer.
Markey's Expressions of Courage exhibit is a yearly art showcase featuring original, artistic expressions connected in some way to an experience with a cancer diagnosis, or crafted by or in memory of a Markey patient whose battle has ended. The exhibit takes place in June, which is National Cancer Survivorship Month.
The Expressions of Courage Gala will help raise funds to support the exhibit, which allows patients and family members to showcase their original art, dance, poetry and music in a celebratory environment.
The Gala will take place at the DoubleTree Suites at Hilton Hotel at 2601 Richmond Road
in Lexington. The gala's events include:
6 p.m. Appetizers, cocktails, and a silent auction
6:30 p.m. Musical performances by Dr. Jay "Zwisch" Zwischenberger and Kayla Smith
7:30 p.m. Buffet dinner
8:45 p.m. Entertainment by the Donnie Brooks Band.
Tickets for the Gala are $50. To purchase tickets, visit ukmarkey.org/markeyevents or buy in person at the Markey Administrative Offices on the first floor of the Ben F. Roach Building at the Markey Cancer Center.
LEXINGTON, Ky. (Dec. 22, 2014) – UK HealthCare has temporarily amended its inpatient hospital visitation policy to be proactive in helping protect the health and well-being of patients and health care workers during this flu season. Visitation restrictions are in effect as of 7 a.m. Monday, Dec. 22.
The measures include:
o No visitors under the age of 12
o No visitors with any symptoms of flu-like illness
o Only two visitors will be permitted in a patient’s room at one time
o Visitors may be issued masks or other protective clothing for use when visiting
o Additional restrictions may be in place in special care units such as women's and children’s units, critical care and oncology units.
o Compassionate visitation exceptions will be made on a case-by-case basis.
"Due to an increasing number of flu cases in Kentucky, UK HealthCare will be instituting these procedures designed to help protect patients, visitors and staff from exposure to the flu and are in effect at all UK HealthCare inpatient units including University of Kentucky Chandler Hospital, Kentucky Children's Hospital, UK Good Samaritan Hospital and Eastern State Hospital," said Kim Blanton, enterprise director for infection prevention and control at UK HealthCare.
Last week, the Centers for Disease Control and Prevention reported that the flu was widespread in 29 of the 54 states and territories that it tracks -- including Kentucky. This time last year, it was widespread in only four.
It is still recommended everyone six months of age and older who hasn't received a flu shot yet, receive one, Blanton said. "A flu vaccine is still the first and best way to prevent influenza," she said.
Flu symptoms can include fever, cough, sore throat, runny or stuffy nose, body aches, headache, chills and fatigue. Flu antiviral drugs are available and work best for treatment when they are started within two days of getting sick. However, starting them later can still be helpful, especially if the sick person has a high risk health condition or is very sick from the flu.
MEDIA CONTACT: Kristi Lopez, 859-806-0445 or firstname.lastname@example.org
LEXINGTON, Ky. (Dec. 15, 2014) – Two University of Kentucky researchers have been awarded $1.62 million in grants through special interest projects from the Centers for Disease Control and Prevention (CDC).
The grants fund projects that focus on methods for improving the dire cancer statistics in Appalachian Kentucky, which has some of the highest rates of cancer incidence and mortality in the country.
Robin Vanderpool, an assistant professor in the Department of Health Behavior in the UK College of Public Health, was awarded a 5-year, $1.37 million grant to fund the Appalachian Center for Cancer Education, Screening, and Support (ACCESS), a collaboration between the University of Kentucky's Rural Cancer Prevention Center (RCPC) and the national Cancer Prevention and Control Research Network (CPCRN).
CPCRN is supported by both CDC and the National Cancer Institute (NCI). ACCESS will work to accelerate the adoption of evidence-based cancer prevention and control programs in Appalachian Kentucky communities and reduce the cancer burden in these underserved populations. The goal of the project is to use existing primary care resources in efficient and effective ways to promote guideline-recommended cancer screenings and improve overall health in the region.
Specifically, ACCESS will conduct a regional research project with White House Clinics, a federally qualified health center that serves a medically underserved and high-poverty region in Appalachian Kentucky. The project will design, implement, and evaluate a proactive officer encounter (POE) intervention effort in eight community health centers, which will provide a systematic approach to offering breast, cervical, colorectal and lung cancer screening services at every office encounter for eligible patients.
Bin Huang, an assistant professor in the Division of Cancer Biostatistics in the Department of Biostatistics, UK College of Public Health, was awarded a 2-year, $250,000 grant to improve Kentucky Cancer Registry (KCR) data through ancillary data linkage. The main goal of Huang's project is to establish groundwork and examine the feasibility for the development of a sustainable Kentucky Cancer Quality and Outcome Research Data System, with the goal of improving the quality of care for Kentuckians with cancer.
The project seeks to generate enhanced KCR data, specifically in Appalachian Kentucky, by linking with external sources such as Medicare, Medicaid, and private insurers; populating treatment summaries for breast and colorectal cancers; and conducting patterns of care research in cancer survival disparities for these types of cancers in Appalachian and non-Appalachian populations.
“These projects are a great example of the interdisciplinary work of investigators in the College of Public Health and Markey Cancer Center that spans the cancer prevention and control continuum, from screening interventions to surveillance, to remedy the cancer disparities faced by residents of Appalachian Kentucky,” said Margaret McGladrey, assistant dean for research in the UK College of Public Health.
Federal funds from the CDC and NCI financed 100 percent of the costs for these special interest projects; no non-governmental sources contributed to the funding.
MEDIA CONTACT: Allison Perry, (859) 323-2399 or email@example.com
Video by UK Public Relations.
LEXINGTON, Ky. (Dec. 10, 2014) – With a table stacked full of pre-cut foam patterns, markers, stamps, and various creative accoutrements, University of Kentucky Markey Cancer Center Art Therapist Fran Belvin is determined to bring a little holiday cheer to the patients and visitors coming through Markey's outpatient clinics.
As patients and visitors walk past her table, many stop to check it out, hesitant. Belvin and her student assistant, Kalin Wilson, welcome them with broad smiles and a simple question: "Would you like to decorate an ornament today?"
Those that say yes sit down and begin to work. Once their creative project is under way, many of the participants begin to tell Belvin about themselves: the treatment they or their loved ones are going through, their struggles, their backstories.
As Belvin notes, there's something about sitting down to work on a creative project that helps people open up and share their feelings. She sees similar reactions from the chemotherapy patients she works with on a daily basis.
"Art therapy is a way for patients to express themselves… a way to explore fears, hopes, and talk about their cancer journey," Belvin said. "Making art and talking about it feels a little less formal, less threatening than if a counselor were to sit down and say, 'Tell me how you're feeling today.'"
Belvin, who began working for Markey as an art therapist in June, spends most of her time visiting patients one-on-on in the chemotherapy suite – or "curtain-to-curtain," as she describes it.
"In addition to helping patients process the emotional effects of their illness, it's also a way to relax and reduce stress," Belvin said. "Chemotherapy can be uncomfortable, it can be boring, and it can be frightening – especially at first. Getting engaged in a creative activity is not only a fun distraction, it puts people in touch with their strengths and increases their positive feelings. In fact, research has shown that art making significantly reduces the stress hormones in the brain and elevates mood."
The ornament table is the second "art event" she's held at the cancer center. Earlier this year, she hosted a "Healing Symbol" table, where she invited participants to create their own personal symbol that represented healing.
Because art therapy is a new addition to the UK Markey Cancer Center's complementary therapy services, Belvin hopes her art events will help spread the word about the services she offers, not just to patients and visitors, but also to healthcare providers who may like to refer their patients to her. Research shows that "creative arts" therapies – including music, art, dance, drama, and writing – significantly reduces anxiety, depression, and pain and improved the quality of life in cancer patients.
Ultimately, Belvin's current ornament table is meant to bring a little levity and stress relief to those passing through the Markey Cancer Center's doors.
"I hope to offer a little bit of brightness while you're going to the doctor's office, where you're not expecting to have a fun, relaxing thing to do," Belvin said. "So I'm hoping this provides a way for people to kind of relax and have a little fun in the middle of their day."
Belvin is hosting two more art therapy ornament-making tables at Markey, both in the first floor lobby of the Whitney-Hendrickson Building. The table will be up again 1-2:30 p.m. today and next Wednesday, Dec. 17, 1-2:30 p.m. Patients, visitors and staff are all welcome to attend and participate.
MEDIA CONTACT: Allison Perry (859) 323-2399 or firstname.lastname@example.org
LEXINGTON, Ky. (Dec. 8, 2014) – University of Kentucky College of Medicine faculty member in behavioral science and Director of the Kentucky LEADS Collaborative Dr. Jamie Studts was featured during the "UK at the Half" that aired during the UK vs. Providence College basketball game, broadcast on the radio Nov. 30.
The Kentucky LEADS Collaborative received a three-year, $7 million grant from the Bristol-Myers Squibb Foundation's Bridging Cancer Care Initiative. Kentucky has more cases of lung cancer than any other state and its lung cancer mortality rate is 50 percent higher than the national average. The collaborative includes the UK Markey Cancer Center, The University of Louisville's James Graham Brown Cancer Center and the Lung Cancer Alliance. The grant funds a three-phase project supporting an increase in primary care provider information, a lung cancer survivorship care initiative and new opportunities in lung cancer screening.
"UK at the Half" airs during the halftime of each UK football and basketball game broadcast and is hosted by Carl Nathe of UK Public Relations and Marketing.
To hear the "UK at the Half" interview click on the play button below. To view a transcript for the Nov. 30 "UK at the Half" interview, click here.
LEXINGTON, Ky. (Oct. 31, 2014) – Coldstream Park will host the city's fourth annual Free to Breathe fundraiser this Saturday, Nov 1. The inspirational event will feature a 5k run/walk and a 1-mile walk for all fitness levels, with awards for top fundraisers and finishers.
All proceeds from the event support Free to Breathe, a nonprofit lung cancer research and advocacy organization dedicated to ensuring surviving lung cancer is the expectation, not the exception.
Kentucky leads the nation in both new incidences of lung cancer and deaths from the disease. Though tobacco use is the biggest risk factor for developing lung cancer, anyone can develop the disease regardless of his or her smoking status. Lung cancer kills nearly twice as many women as breast cancer, and it is the leading cause of cancer deaths for both men and women in the U.S. Despite this, lung cancer receives proportionately less government funding per death than other types of cancer.
Free to Breathe aims to rally Kentuckians to create change and help defeat lung cancer. Supporters and participants are creating communities of hope by raising awareness of the disease and funds which can fuel advances in detection and treatment and ultimately save lives.
Registration for the event will begin at 8:30 a.m. Saturday, followed by the opening rally at 9:40 a.m. The cost to register that day is $30. Registrants can choose to participant in one of three events:
· 5K Run, beginning at 10 a.m.
· 5K walk, beginning at 10:05 a.m.
· 1-mile walk, beginning at 10:10 a.m.
For more information on Free to Breathe, visit www.freetobreathe.org.
LEXINGTON, Ky. (Oct. 29, 2014) – The University of Kentucky Markey Cancer Center has
signed a memorandum of cooperation to collaboratively study lung cancer with the Nanjing
Medical University in the Jiangsu Province, China.
Earlier this month, Dr. Mark Evers, director of the UK Markey Cancer Center, and Daret St. Clair, associate director for basic research, visited Nanjing Medical University to sign the memorandum with Nanjing Medical University Chancellor Shen Hongbin agreeing to collaborate on future projects in cancer research.
The initial contact between the two institutions developed with the exchange of researchers and clinicians between St. Clair’s laboratory and Nanjing Medical University Affiliate Hospital, the first Nanjing Hospital. Markey's strength in basic research was a collaborative match with Nanjing Medical University investigators who have specific expertise in the genetic and epigenetic analyses of lung cancers.
Kentucky has the highest mortality rate of lung cancer in the U.S., but lung cancer is also a common disease in China.
“Cancer is a global problem,” Evers said. “This partnership with Nanjing Medical University will establish collaborative ties with their talented investigators as we work together to fight cancers that have a high incidence in both Kentucky and China.”
In addition, there may be opportunities to share clinical trial expertise between the two institutions.
“This is an excellent example of how the Markey Cancer Center continues to expand its network and reach, not only regionally but globally as well,” Evers said.
LEXINGTON, Ky. (Oct. 23, 2014) – The University of Kentucky Markey Cancer Center's Jin Shin Jyutsu practitioner Jennifer Bradley will be the featured guest on SiriusXM Family Talk Channel 131's "Aches and Gains" with Dr. Paul Christo the next two Saturdays.
Originally scheduled for just one show, Bradley's interview was expanded to two. The first airs Saturday, Oct. 25 at 5 p.m., with the second installment airing Saturday, Nov. 1 at 5 p.m. Podcasts are accessible after the show at www.paulchristo.com.
Jin Shin Jyutsu (JSJ) is an ancient form of touch therapy similar to acupuncture in philosophy. Bradley, a licensed practitioner, originally began offering free JSJ sessions to patients as a Markey volunteer in 2009. In 2010, she received a $49,000 initial grant from the Lexington Cancer Foundation to provide the touch therapy to cancer patients full-time. Since then, Bradley has offered up to five free sessions to Markey patients at no charge.
JSJ is considered part of an integrative treatment plan at the UK Markey Cancer Center. Patients may self-refer, though many patients currently seen are referred by their physician or Markey staff.
During a session, patients receive light touches on 52 specific energetic points called Safety Energy Locks as well as fingers, toes, and midpoints on the upper arm, upper calf and lower leg in predetermined orders known as "flows." Patients remained clothed except for shoes and all hand placements are done over clothing.
LEXINGTON, Ky. (Oct. 22, 2014) – In 1994, University of Kentucky alumna Cathy Bell was diagnosed with breast cancer – for the first time.
Because she had a family history of the disease (her grandmother fought breast cancer), she began having mammograms at an earlier age than most. And during her baseline mammogram at age 39, her doctors discovered an unusual pattern of calcifications, and ultimately, a malignancy.
Treatment quickly followed – a lumpectomy (a breast-conserving surgery) and radiation. Bell, then a busy elementary school principal, says she was mainly concerned about getting back to work.
"I had a school to run and needed to get past that 'bump in the road' and return to my duties," she said.
Ultimately, Bell only missed four days of school. She headed back to work as soon as she could, fitting in an hour of daily radiation into her schedule. When her treatment was completed, she thought she was done.
"I thought I had moved past it," she said.
Local recurrence, or the return of a cancer to its original location, is a relatively uncommon circumstance. Most of the time, a local recurrence will happen within the first five years following diagnosis.
However, in a few instances, a local recurrence can happen many years down the road. In Bell's case, she was nearly two decades cancer-free before receiving that sobering diagnosis for a second time.
In 2013, she noticed an unusual pain under her arm. Though she'd had a regular mammogram only six months earlier, she went back to her doctor for another. The results showed a similar pattern of unusual calcifications in the same breast – her cancer had returned.
Now retired, Bell says she spent a great deal of time researching treatment for breast cancer, and her investigations led her to University of Markey Cancer Center breast surgical oncologist Dr. Patrick McGrath. Because she'd undergone radiation therapy previously, Bell could not use that treatment again, which is commonly paired with a lumpectomy.
Instead, she opted for a bilateral mastectomy with delayed reconstructive surgery. Additionally, she underwent genetic counseling at Markey to determine if she carried the BRCA1 or BRCA2 gene mutation – a test she did on behalf her sisters, who are now considered "high risk" due to having two close family members with breast cancer. Luckily, Bell's results were negative.
Bell, an avid writer, says she turned to poetry to help work through her emotions after her second diagnosis. Shortly before her surgery, she composed a piece titled "This One is About Me." The poem, written in a catchy cadence with humor sprinkled throughout, served another purpose – to give her friends and family information on her health straight from the source and help them understand what she was going through.
"I turned to creativity to deal with my issues," she said. "That's how I dealt with all that information."
Shortly after she wrote her poem, Bell received a letter from the UK Markey Cancer Center inviting her to participate in the center's inaugural "Expressions of Courage" event, a creative exhibit showcasing original artistic expressions created by cancer patients, friends and family. Bell immediately knew she wanted to participate.
"I thought, wow, I already have this done!" she said.
Contributing to Expressions of Courage was just one way Bell has given back. She notes that she "loves UK" and supports the Markey Cancer Foundation and other cancer research organizations when she can. And having gone through the difficulties of dealing with breast cancer not once, but twice, she says her role now is to help others deal with their own diagnoses and to help in any way she can, noting that sometimes that just means lending an ear. She is frequently called up by friends or family members affected by breast cancer, who are seeking help and understanding for themselves or on behalf of a loved one.
"This is just the way it's supposed to be," Bell said. "I feel like I'm here to help other people… Famous people may write a book or talk publicly, but that's not my style. I'm a good listener when I need to be."
Earlier this year, Bell was dealt another small setback when she was diagnosed with squamous cell carcinoma in her lip. After undergoing Mohs surgery, the former UK cheerleader was back to living her life yet again, staying busy in retirement – and remaining eternally optimistic.
"It's just what I've been dealt," she says. "I love life and I want to keep living it!"
LEXINGTON, Ky. (Sept. 19, 2014) – Kentucky faces some of the highest rates of cancer incidence and mortality in the nation, but Methodist Hospital in Western Kentucky is stepping up the fight against cancer. The Methodist Hospital organization in Henderson, Ky., has announced a new affiliation with the University of Kentucky Markey Cancer Center, the state's first and only National Cancer Institute-designated cancer center.
Methodist Hospital CEO Bruce Begley said the announcement meant great things for their patients.
“The Methodist Hospital affiliation with the UK Markey Cancer Center brings to this region nationally ranked cancer treatment close to home," Begley said. "We believe this is a big step in the continuing battle against cancer, and I appreciate UK HealthCare's overall mission of extending high-quality cancer care to all Kentuckians.”
"We are extremely excited and proud for our cancer care program to become an affiliate of the Markey Cancer Center," said Dr. Arshad Husain, medical director of hematology and oncology at Methodist Hospital. "This alliance means great things for our patients. It will enable us to offer access to the latest practices in diagnosis and treatment of cancers and blood disorders, including clinical trials – thus providing a higher level of cancer care in our neighborhood."
The UK Markey Cancer Center Affiliate Network was created to provide high-quality cancer care closer to home for patients across the region, and to minimize the effects of cancer through prevention and education programs, exceptional clinical care, and access to research.
Methodist Hospital in Henderson is a 192-bed acute care facility and is just one facet of the Methodist Hospital Healthcare system. Other facilities serving the area include
Methodist Hospital Union County, a critical access hospital in nearby Morganfield, Ky., and 19 outpatient physician offices with 47 providers over a four-county service area.
By becoming a UK Markey Cancer Center Affiliate, Methodist Hospital is in keeping with the organization’s mission to provide safe, compassionate, high quality, and cost-effective services to the communities served. The Methodist Hospital Healthcare system will now be able to offer their patients access to additional specialty and subspecialty physicians and care, including clinical trials and advanced technology, while allowing them to stay in western Kentucky for most treatments.
The Markey Cancer Center Affiliate Network supports UK HealthCare's overall mission of ensuring no Kentuckian will have to leave the state to get access to top-of-the-line health care.
"UK HealthCare doesn't just serve Lexington and central Kentucky – our mission is to provide all Kentuckians with the best possible care right here in the state," said Dr. Michael Karpf, UK executive vice president for health affairs. "The Markey Cancer Center Affiliate Network allows us to collaborate with community hospitals to provide top-notch cancer care much closer to home -- saving both travel expenses and time for the patients, in addition to keeping them close to their personal support system."
Markey is one of only 68 medical centers in the country to earn an NCI cancer center designation. Because of the designation, Markey patients have access to new drugs, treatment options and clinical trials offered only at NCI centers.
Moving forward, the Markey Cancer Center is working toward the next tier of designation – an NCI-designated Comprehensive Cancer Center. Currently, 41 of the 68 NCI-designated cancer centers in the country hold a comprehensive cancer center status. The Markey Cancer Center Affiliate Network will play a large role in bringing that next level of cancer funding to Kentucky.
"The burden of cancer in Kentucky is huge, and unfortunately we have some of the worst cancer rates in the country," said Dr. Mark Evers, director of the UK Markey Cancer Center. "By collaborating with our affiliate hospitals across the state, we have the potential to make a serious impact on cancer care here in the Commonwealth."
The UK Markey Cancer Center Affiliate Network began in 2006 and comprises 12 hospitals across the state of Kentucky:
Evaluations are under way for several other hospitals, including two more outside the state of Kentucky, extending Markey's reach and establishing it as the destination cancer center for the region.
LEXINGTON, Ky. (Sept. 18, 2014) - To celebrate Ovarian Cancer Awareness Month, cancer survivors and UK faculty and staff participated in a special tailgating event called "tealgating" eariler this month.
The event further helped create awareness about the UK Ovarian Screening Program, an ongoing study that uses transvaginal ultrasound to detect ovarian cancers. Women over age 50 and women over age 25 who have a family history of ovarian cancer are eligible for the free program.
More than 43,000 women have participated in the UK Ovarian Screening Program and more than 256,000 free ultrasound screens have been done through the program. Women from every county in Kentucky have participated in the program ane more than 85 malignancies have been detected.
For more information on the program or to schedule an appointment, visit http://ovarianscreening.info.
LEXINGTON, Ky. (Sept. 16, 2014) – Dr. Edward M. Wolin, a nationally known expert in treating neuroendocrine and carcinoid tumors, has joined the team at the University of Kentucky Markey Cancer Center.
Neuroendocrine tumors develop from endocrine cells found in the digestive tract, lungs, pancreas, and other sites. These rare cancers present unique diagnostic challenges. They tend to be slow-growing, and usually have metastatic disease at the time of diagnosis.
At Markey, Wolin will serve as the director of the Carcinoid and Neuroendocrine Tumor Program. In addition to working with Markey's team of surgical and radiation oncologists, pathologists, and diagnostic radiologists, Wolin will collaborate on patient care with UK Chief of Medical Oncology Dr. Lowell Anthony. Anthony came to UK in 2011 and helped build up Markey's Neuroendocrine Clinic, the region's first multidisciplinary clinic dedicated to endocrine and neuroendocrine tumors.
Wolin brings a robust research program to Markey, including multiple clinical trials. His research efforts focus on finding treatments which are more effective and less toxic, including pasireotide, lanreotide, everolimus, other m-tor inhibitors, targeted radiation including peptide receptor radiotherapy with Lu-177, anti-angiogenic drugs, novel targeted biologic anti-cancer treatments, and targeted treatment of liver metastases. Wolin's research is also directed at development of new imaging and diagnostic procedures for carcinoid/neuroendocrine tumors.
"Dr. Wolin is renowned for his skill in treating these complex forms of cancer, and we are thrilled to bring his expertise to our patients here in Kentucky," said Dr. Mark Evers, director of the UK Markey Cancer Center. "Through his clinical trials, many patients will be able to receive extremely specialized care that they couldn't get anywhere else in the country."
Wolin earned his medical degree at Yale University School of Medicine. He performed his internship, residency and a medical oncology fellowship at Stanford University Medical Center followed by a clinical fellowship at the National Cancer Institute in Bethesda, Maryland. Prior to coming to Markey, he served as co-director of the Cedars-Sinai Carcinoid and Neuroendocrine Tumor Program at Cedars-Sinai Medical Center in Los Angeles.
Wolin sees patients in the Multidisciplinary Clinic on the first floor of the UK Markey Cancer Center's Whitney-Hendrickson building. To make an appointment, call 859-257-4488 or toll free 866-340-4488.
LEXINGTON, Ky. (Sept. 15, 2014) – A new study by University of Kentucky researchers has identified a novel molecule named Arylquin 1 as a potent inducer of Par-4 secretion from normal cells. Par-4 is a protein that acts as a tumor suppressor, killing cancer cells while leaving normal cells unharmed.
Normal cells secrete small amounts of Par-4 on their own, but this amount is not enough to kill cancer cells. Notably, if Par-4 secretion is suppressed, this leads to tumor growth.
Published in "Nature Chemical Biology," the UK study utilized lab cultures and animal models to show that low levels of Arylquin 1 induced Par-4 secretion without causing harm to the producer cells.
Additionally, researchers found that Par-4 is bound to a protein called vimentin, which contributes to tumor metastasis. Arylquin 1 binds to vimentin, displacing the Par-4 for secretion -- which means it may also be useful for inhibiting the spread of cancer.
These findings have strong implications for the development of future cancer treatments, as researchers are now focusing on developing Arylquin 1 into a drug to inhibit both primary and metastatic tumors.
"We found that Par-4 is inactivated by pro-metastasis proteins such as vimentin," said Vivek Rangnekar, UK professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine. "This implies that by using small molecule drugs that target metastasis proteins, we may be able to both inhibit the spread of cancer while also releasing the tumor suppressor -- Par-4 -- to then induce the death of the cancerous cells."
Rangnekar, who also serves as associate director for the UK Markey Cancer Center, initially discovered the Par-4 gene in 1994. Working closely with UK medicinal chemist David Watt and a multidisciplinary team across the UK campus, their labs are developing secretagogues that can cause elevated secretion of Par-4 for the inhibition of primary and metastatic tumors.
This study was funded by grants from the National Cancer Institute, the National Center for Research Resources, and the UK Center for Clinical and Translational Science.
LEXINGTON, Ky. (Sept. 15, 2014) -- Did you know that you can help others by participating in research? Health-focused research affects every aspect of our lives, from the medications we take to the health of our environment. Researchers are working hard to identify new treatments and strategies to improve the health of our communities, but research needs healthy volunteers and volunteers with medical conditions in order to succeed. Participating in research is a safe, easy way for you to give back to your community and give hope for the future while learning more about your own health.
Find out how you can participate in research during the University of Kentucky's next #AskACat Twitter chat, beginning 2 p.m. Tuesday, Sept. 16, at @universityofky. UK researchers will answer general questions about participating in research. They will also answer questions about ResearchMatch, a registry that pairs volunteers with researchers looking for participants, and UK's new Research Registry and Specimen Bank, or the "biobank." For more information on ResearchMatch, visit www.researchmatch.org/?rm=@AskaCat.
UK patients are being invited to help researchers by allowing leftover blood and tissue from their normal medical procedures to put into the biobank. For example, when a patient undergoes a blood draw or tissue biopsy, the blood or tissue that isn’t used for testing is normally thrown away. In the new biobank project, however, patients will be given a consent form to allow any “leftover” blood or tissue from their regular medical procedures to be stored in the biobank for research purposes. No additional procedures will be performed or extra blood or tissues collected whatsoever. Participation is voluntary, and to protect patient privacy, all identifying information (such as name, address and social security numbers) will be removed from the samples and corresponding medical records.
Four UK experts will respond to questions during the chat:
· Belinda Smith, education specialist at the Office of Research Integrity;
· Ada Sue Selwitz, director of the Office of Research Integrity;
· Dr. Susanne Arnold, associate professor in medical oncology and radiation medicine and associate director for clinical translation at the Markey Cancer Center; and
· Dr. Phil Kern, director of the Center for Clinical and Translational Science and the Barnstable Brown Diabetes and Obesity Center.
Join the conversation or follow the chat at the university's official account @universityofky, or use the hashtag #AskACat for questions and responses from the Twitter chat.
Individuals interested in asking questions about participation in health care research, ResearchMatch, or the biobank can send their questions to twitter.com/universityofky through 3 p.m. Sept. 16, or to the UK Facebook page prior to 2 p.m., Sept. 16. Responses to questions will be shared with the university's Twitter followers and those following the hashtag #AskACat.
UK will present its next #AskACat Twitter chat Oct. 21.
MEDIA CONTACT: Whitney Hale or Elizabeth Adams, 859-257-1754
LEXINGTON, Ky. (Sept. 3, 2014) – Hardin Memorial Health celebrated a new affiliation between its Cancer Care Center and the University of Kentucky Markey Cancer Center, the state's first and only National Cancer Institute-designated cancer center.
"The Markey affiliate agreement provides a great opportunity for professional education and training for our staff and physicians," said Hardin Memorial Health President Dennis Johnson. "Collaboration with Markey and their affiliates across the state allows our team to stay up-to-date on the newest cancer treatments and research."
"There is no reason for cancer patients in central Kentucky to leave this area to seek treatment, because the HMH Cancer Care Center provides personalized cancer care close to home," said Dr. Adam Lye, medical director of the Hardin Memorial Health Cancer Care Center. "This care can be enhanced when combined with Markey's specialized treatment, technology and clinical trial opportunities that will help us take cancer care to the next level. This is great news for cancer patients and their families in our community."
By joining the UK Markey Cancer Center Affiliate Network, the HMH Cancer Care Center will be able to offer their patients access to additional specialty and subspecialty physicians and care, including clinical trials and advanced technology, while allowing them to stay closer to home for most treatments. The Markey Cancer Center Affiliate Network supports UK HealthCare's overall mission of ensuring no Kentuckian will have to leave the state to get access to top-of-the-line health care.
The UK Markey Cancer Center Affiliate Network began in 2006 and comprises eleven hospitals across the state of Kentucky:
To protect the health of the patients we serve this flu season, UK HealthCare has made temporary changes to Bone Marrow Transplant visitation policies. Read more »
Para proteger la salud de las personas a quienes atendemos durante esta temporada de influenza, UK HealthCare ha hecho cambios temporales a los reglamentos en cuanto a visitas. Más »
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