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Heidi L. Weiss, PhD

Cancer Center Member

Markey Research Programs:
    Drug Discovery, Delivery and Translational Therapeutics

Associate Director, Shared Resources and Director, Biostatistics Shared Resource Facility

Professor

Department of Surgery ›
College of Medicine ›

Research Focus

Design and analysis of early phase clinical trials focusing on Bayesian design and interim monitoring. Statistical analysis of transgenic, xenograft and chemically induced mouse models of cancer.

Contact Information

800 Rose Street
CC448 Roach Building
University of Kentucky
Lexington Kentucky 40536

Key Publications

  1. Massarweh S, Tham YL, Huang J, Sexton K, Weiss H, Tsimelzon A, Beyer A, Rimawi M, Cai WY, Hilsenbeck S, Fuqua S and Elledge R. A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer. Breast Cancer Res Treat 129:819-27, 2011.
  2. Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R. Bayesian Monitoring of a phase II chemoprevention trial in high risk cohorts for prostate cancer. Urology 57(4A):220-223, 2001.

Recent Publications

(five most recent publications via an automated list from PubMed, based on researcher’s ID and the University of Kentucky)
  1. Wen YA, Li X, Goretsky T, Weiss HL, Barrett TA, Gao T.
    Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.
    Biochim Biophys Acta. 2015 Jul.
  2. Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T, Evers BM.
    Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration.
    Oncotarget. 2015 Apr.
  3. Kim JT, Liu C, Zaytseva YY, Weiss HL, Townsend CM, Evers BM.
    Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.
    Int J Cancer. 2015 Mar;136(6):1475-81.
  4. Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee EY, Mustain W, Valentino J, Guo P, Evers BM.
    Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration.
    ACS Nano. 2015 Feb;9(2):1108-16.
  5. Zhou Y, Rychahou P, Wang Q, Weiss HL, Evers BM.
    TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.
    Cell Death Dis. 2015;6:e1631.